A number of more recent discoveries in microbiology have made reliable identification of nano-biomolecules and extensive analyses of them necessary. A variety of proteins, including DNA, biotin-streptavidin, amino acids, as well as many types of bacteria and viruses, must be found and analyzed in order to fully comprehend any odd behavior occurring inside of live cells. Rapid testing and detection are essential steps in preventing undiscovered biohazards from eradicating the human race and other terrestrial living things. Since many decades ago, developing an accurate, affordable biosensor has been a struggle for scientists . When compared to pricey laboratory-based sensors and detection methods, FET-based lab-on-chip nano biosensors appear to be a promising substitute. It is significantly more dependable than conventional bulk sensors because of its size, affordability, low power consumption, resilience, faster response time, and better sensitivity . Due to their precision, adaptability, and compatibility with embedded systems, dielectrically modulated FET biosensors with Nano cavities are emerging as a promising research area that can yield useful data on bio-analyses. As an alternative to conventionally doped TFET devices, using a charge plasma SiGe-heterojunction double gate TFET, a label-free biosensor can be produced, bypassing the need for conventional semiconductors, which require a large thermal budget and are susceptible to random dopant fluctuations (RDFs). The effect of changing the dielectric constant (k), the positive and negative charge density, the gate work function, and the cavity size has been investigated to better understand how these factors affect the performance of the proposed biosensor. These parameters modify the biosensor's electric characteristics, improving detection . There is also discussion of how these factors influence the device's drain current, electric field, surface potential, sub-threshold swing (SS), insulator-to-metal film (ION/IOFF) ratio, and electron tunneling rate (ETR). The sensitivity of the drain current in the proposed biosensor is also investigated. There is no restriction on whether or whether the proposed structure is used for charged or neutral molecules. Under lower supply voltages, it is discovered that the SG-DM current JLFET's sensitivity is high, measuring 1.2 *10^3, with a potential sensitivity of 1.4 V. A result, the SG-DM  JLFET exhibits good application potential while consuming little power and having a high sensitivity.