In this Study, the weight percentages of different reinforcements are added in Nylon66 parent material in order to enhance its mechanical, tribological properties of pure Nylon66 Composite. Test specimens of pure Nylon66 with different weight percentages of reinforcements are prepared by using an injection molding machine. Various tests are conducted on new polymer matrix composite was carried out the tribometer or pin on disk setup is done to study the wear charactristics of the material. The obtained result reveal that the mechanical properties as well as tribological properties of the newly prepared Nylon composite are significantly increased by the weight percentage of MoS2 (molebdenum disulphide) reinforcement material , here pure Nylon indications the lowest tensile strength as compared to newly formed Nylon composite material. This paper summarized, the parametric influence of Reinforcement, temperature and load on wear rate of nylonn 66 material with MoS2 reinforcement. Response surface methodology (RSM) and Taguchi method is used for modelling and optimization. ANOVA has been carried out to identify importance of the operating parameters on the performance characteristics considered. Further the verification experiment has been carried out to confirm the performance of optimum parameters. The results from this study will be useful for selecting appropriate set of process parameters has been selected. The analysis of variance (ANOVA) has been used to determine effect of each parameter on wear rate so Finally, the confirmation test has been carried out to compare the predicted value of wear rate with the experimental value