Objective- A software tool is developed to facilitate data entry and to monitor research projects in under-resourced countries in real-time. In this paper, we are working in three projects which have used ODK platform- PMA (1), CNN (2), PMA in Agile (3). Along with this, we are also emphasizing the fact that in the modern era, data collection can be done without paper-pen. Method- The e Management tool “Open Data Kit, (ODK) is written in the scripting language Python. The ODK is lightweight and uses minimal internet resources. It was designed to be used with the open-source software ODK. The users can easily configure ODK to meet their requirements, and the online interface displays data collected from ODK forms in a graphically informative way. The tool also allows users to upload pictures and laboratory results and sends text messages automatically. User-defined access rights protect data and privacy. (4) Results- We present examples from four field applications in Tanzania successfully using the e Management tool: 1) clinical trial; 2) longitudinal Tuberculosis (TB) Cohort Study with a complex visit schedule, where it was used to display missing case report forms graphically, , upload digitalized X-rays, and send text message reminders to patients; 3) intervention study to improve TB case detection, carried out at pharmacies: a tablet-based electronic referral system monitored referred patients, and sent automated messages to remind pharmacy clients to visit a TB Clinic; and 4) TB retreatment case monitoring designed to improve drug resistance surveillance: clinicians at four public TB clinics and lab technicians at the TB reference laboratory used a smartphone-based application that tracked sputum samples, and collected clinical and laboratory data. Conclusions The user-friendly, open-source ODK planner is a simple multi-functional, Web-based e Management tool with add-ons that helps researchers conduct studies in under-resourced countries.