: Pilot sequence plays a significant role in telecommunication, but the occurrence of pilot contamination reduces the efficiency of the system leads to an overall deterioration in the performance of massive Multiple Input Multiple Output (MIMO). Numerous techniques are introduced to reduce the occurrence of the pilot contamination in order to improve the efficiency of the MIMO systems. In this research, the pilot contamination problem is optimized using the formicidae physarum (FP) based optimization due to the fact that is provides approximate solution even in complex situations. The proposed scheduling algorithm is examined based on the uplink achievable rate and SINR rate with respect to the number of users, antennas, transmission power and fading factor which provides attainable results. The proposed method attained 43.423 bps/Hz upper link achievable rate and 13.582 bps/Hz SINR which is quiet efficient in avoiding pilot contamination.