The large number of automobiles in use around the world has caused and continues to cause serious problems of environment and human life. Air pollution, global warming, and the rapid depletion of the earth’s petroleum resources are now serious problems. Electric Vehicles (EVs), Hybrid Electric Vehicles (HEVs) and Fuel Cell Electric Vehicles (FCEVs) have been typically proposed to replace conventional vehicles in the near future. Most electric and hybrid electric configurations use two energy storage devices, one with high energy storage capability, called the “main energy system” (MES), and the other with high power capability and reversibility, called the “rechargeable energy storage system” (RESS). MES provides extended driving range, and RESS provides good acceleration and regenerative braking. Energy storage or supply devices vary their output voltage with load or state of charge and the high voltage of the DC-link create major challenges for vehicle designers when integrating energy storage / supply devices with a traction drive. DC-DC converters can be used to interface the elements in the electric power train by boosting or chopping the voltage levels. Due to the automotive constraints, the power converter structure has to be reliable, lightweight, small volume, with high efficiency, low electromagnetic interference and low current/voltage ripple. Thus, in this chapter, a comparative study on three DC/DC converters topologies (Conventional step-up dc-dc converter, interleaved 4-channels step-up dc-dc converter with independent inductors and Full-Bridge step-up dc-dc converter) is carried out. The modeling and the control of each topology are presented. Simulations of 30KW DC/DC converter are carried out for each topology. This study takes into account the weight, volume, current and voltage ripples, Electromagnetic Interference (EMI) and the efficiency of each converter topology.