[This article belongs to Volume - 54, Issue - 02]
Gongcheng Kexue Yu Jishu/Advanced Engineering Science
Journal ID : AES-26-12-2022-53

Title : PALLADIUM CATALYZED SYNTHESIS OF FIVE-MEMBERED NITROGEN-CONTAINING HETEROCYCLES
Kamlesh Sharma, Karishma Rawat, Priyanka, Manisha T Sharma

Abstract :

Palladium is the most versatile metal in the transition series. Palladium can initiate a wide variety of organic reactions such as arylation, alkylation, hydrogenation, cyclization, oxidation, cross-coupling, isomerization, radical reactions, cascade, etc. Most of these reactions occur in mild conditions. It can be used in both laboratory and industrial scale. Despite many uses of palladium, new novel and efficient methods are still exploring. Now the focus is more towards sustainability of the process. This article focuses on the synthesis of five-membered nitrogen-containing heterocycles using palladium as a catalyst. Heterocycles plays an important role in pharmaceuticals, agrochemicals and as veterinary products. Some of the natural products e.g. antibiotics and alkaloids have heterocyclic moiety. In this study, we have included palladium catalyzed synthesis of pyrroles, pyrrolidines, imidazolidines, pyrazoles, triazoles and tetrazoles of last one decay.