In this study, Lithium Zinc telluroborate glasses incorporated with Lanthanum nanoparticles (LZTBLn) were prepared using the conventional melt-quenching method. The density and molar volume of the glasses were calculated. XRD analysis confirmed that all samples are amorphous in nature. The radiation shielding ability of the glasses was evaluated using computational simulation technique. Shielding parameters such as the Linear attenuation coefficient (LAC), Mass attenuation coefficient (MAC), Effective atomic number (Zeff), Half- value layer (HVL), Tenth-value layer (TVL), and Mean free path (MFP) were determined over a wide range of photon energies (0.015-15MeV). The results show that increasing the La2O3 nanoparticles content improves the radiation shielding performance than other traditional shielding materials. These findings suggest that La2O3 doped lithium zinc telluroborate glasses are promising, lightweight, and non-toxic materials for radiation shielding applications.