In this paper, the onset of convective instabilities in a Jeffrey fluid saturated with rotating anisotropic porous medium is investigated in the presence of thermodiffusion. The problem for the convection-enhanced delivery system with anisotropy in porous media is modeled using the Darcy-Brinkman-Jeffrey constitutive relation. Such configuration plays a significant role in many bio-medical applications for precise delivery of fluids in taking advantage of controlled porous convection. The linear stability analysis is performed using the classical normal mode technique and the stability parameter thermal Rayleigh number is determined. The results are depicted pictorially and compared with previous published outcomes. It is observed that the rotations, relative effect of permeability, and thermal anisotropy stabilize the system in both stationary and oscillatory convective modes. The Jeffrey fluid parameter, mechanical anisotropy, solute buoyancy and thermodiffusion destabilize the system in stationary mode and stabilize the system in oscillatory mode whereas effects are dual in case of Lewis number.