The paper discusses the critical importance of data ecosystems within cloud-native environments designed for predictive and automated decision-making systems in healthcare. The evolving requirements for healthcare service delivery necessitate an alternative architectural paradigm that goes beyond traditional monolithic systems and monolithic software applications hosted in dedicated private data centers or single public cloud infrastructures. Service-oriented deployments are best modeled using microservices and service meshes, data contracts, and independent deployments. Precision healthcare addresses disease prevention, detection, forecasting, diagnosis, management, and outcome prediction for individuals or specific population sets. It leverages underlying compute, storage, and networking services designed for traditional enterprise workloads with strict recoverability and business continuity requirements. Frameworks for scalability, resilience, and disaster recovery translate elasticity features from the public cloud domain, while supporting cloud-native solutions in hybrid or multi-cloud environments. The success of such an approach is entirely dependent on effective data protection techniques, access controls, and the ability to demonstrate compliance with multiple regulations.